Please consult your doctor if you are taking any other prescription medications before taking AZO Urinary Tract Defense. AZO Urinary Tract Defense should not be taken with sulfonamide drugs. Products that decrease the acidity of the urine (such as antacids, sodium bicarbonate, potassium or sodium citrate, carbonic anhydrase inhibitors such as acetazolamide) may reduce the effectiveness of AZO Urinary Tract Defense. AZO Urinary Tract Defense should not be taken with anticoagulants, steroid drugs, or in addition to other non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen and others).